Comparative Characteristics of Dosage Forms of α-Lipoic Acid

Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms

The present study aimed to examine the enantiomer-selective pharmacokinetics (PK), relative bioavailability (Frel), and sex effects of various oral dosage forms of racemic alpha-lipoic acid (ALA). In an open-label, randomized, four-period, four-sequence crossover study, 24 healthy adult subjects (12 males and 12 females) received single doses of 600 mg of ALA in fasted state at four different o...

Effect of α-lipoic Acid on Hemolytic Activity of Iranian Vipera Lebetina Venom

Abstract Background and Objective: Snake venom is a complex of several toxic elements and enzymes. It has the agents with the ability to destroy cellular and subcellular membrane and to bring about hemolysis of red blood cells (RBC). Two types of direct and indirect hemolytic activity are known in snake venom in that phospholipase A2 is responsible for the indirect lysis. The aim of this st...

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

Design, Evaluation and Comparative Study of Pulsatile Release from Tablet and Capsule Dosage Forms

      The objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (DDS) for Metoprolol tartarate (MT) as tablet and capsule. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal del...

Voltammetric Determination of α-Lipoic Acid using Poly(Vanillin) Modified Platinum Electrode

In the present study electrochemical detection of α-lipoic acid (α-LA) was carried out with a poly(Vanillin) modified platinum electrode p(VA)/PtE in Brinton Robinson buffer (BR) solution. The platinum electrode surface’s was modified with cyclic voltammetry method. The prepared Pt electrode was characterized by cyclic voltammetry in ferrocyanide and scanning electron microscopy (SEM) images. T...